2018 Edogawa NICHE prize Awardee

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Prof. Dr. James Edgar Till

Professor Emeritus, University of Toronto

As the subject of the association being around regenerative medicine and that the fundamental origin of this new specialty per se is after the discovery of stem cells, the Jinseisha- NCRM Edogawa Niche Prize committee has unanimously decided to honour Prof. James Edgar Till for his discovery of stem cells jointly with Prof. Ernest McCulloch with the Edogawa NICHE prize in the first year of its establishment in 2018.

Brief profile* of Prof. James E. Till

Dr Till was born in Lloydminster Saskatchewan and received a bachelor of Arts in 1952 and Master of Science in 1954 in physics at the University of Saskatchewan having received scholarships from the National Research Council and Standard Oil Company. Dr Till then went on to receive a PhD at Yale University in biophysics in 1957. He was then recruited to the Ontario Cancer Institute at Princess Margaret Hospital as a post-doctoral fellow at the University of Toronto.

It was there he met Dr Ernest McCulloch and together they conducted their ground breaking work involving injection of bone marrow cells into irradiated mice. They made the sentinel observation of finding clones of cells within the spleen, although at that time they called them lumps. This first work was published in the journal Radiation Research in 1961. They showed that these marrow cells were capable of self renewal and this work established the concept of multilineage stem cells which was published in Nature and Journal of Cellular and Comparative Physiology in 1963.

His work has had huge application in the field of bone marrow transplantation, the treatment of cancer and tolerance induction.

Dr Till has received many honors for his groundbreaking discoveries including election as an officer of the Order of Canada in 1994, the Order of Ontario in 2006, appointment as a Fellow to the Royal Society of London, induction to the Canadian Medical Hall of Fame in 2004 and was awarded with his friend and collaborator Dr McCulloch the Albert Lasker Award for Basic Medical Research.

Perhaps the greatest testimony to Dr Till has been the training of other great scientists including Dr Norman Iscove, Dr Robert Phillips and Dr Ron Worton and also that Toronto continues to be a great world stem cell center.

* based on an introduction by Prof. Gary Levy at the award ceremony in 2018